General Information

  • ID:  hor002833
  • Uniprot ID:  Q8T0Y7
  • Protein name:  Neuropeptide CP2
  • Gene name:  CP2PP
  • Organism:  Aplysia californica (California sea hare)
  • Family:  NA
  • Source:  animal
  • Expression:  Neurons.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FDFGFAGLDTYDAIHRALEQPARGTSNSGSGYNMLMKMQRH
  • Length:  41(100-140)
  • Propeptide:  MDSRICTSFARLMASALCVSTLLVTAMPFDLRRGSSDTDLDLQGHVDLGLDDLDKLRLIFPPGLIEEAFSQAQGKVDMPLPRQRTSSRSSERWAPKSKRFDFGFAGLDTYDAIHRALEQPARGTSNSGSGYNMLMKMQRHG
  • Signal peptide:  MDSRICTSFARLMASALCVSTLLVTA
  • Modification:  T41 Histidine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates intrinsic neuromodulation
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q8T0Y7-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002833_AF2.pdbhor002833_ESM.pdb

Physical Information

Mass: 530578 Formula: C199H301N59O61S3
Absent amino acids: CVW Common amino acids: G
pI: 7.7 Basic residues: 6
Polar residues: 14 Hydrophobic residues: 11
Hydrophobicity: -60 Boman Index: -8497
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 47.8
Instability Index: 3451.71 Extinction Coefficient cystines: 2980
Absorbance 280nm: 74.5

Literature

  • PubMed ID:  11786187
  • Title:  Cloning, Expression and Processing of the CP2 Neuropeptide Precursor of Aplysia